The "Dope Show" video, directed by Paul Hunter and co-directed by [[Marilyn Manson|Manson]], was filmed during the week of August 8, 1998, and premiered on August 20, 1998. In scenes reminiscent of ''The Man Who Fell to Earth'', Manson appears — red-haired, with his entire body, including prosthetic rubber breasts, covered in white grease paint — as an androgynous extraterrestrial wandering around the Hollywood Hills. He is captured, studied in a laboratory, and eventually transported by limousine to a stage where he and the other members of the band — the fictional band Omēga and the Mechanical Animals — perform the song in concert before hysterical fans who end up rioting and crossing the security barriers. Actor Billy Zane makes a cameo appearance in the limo sequence, as a recording industry executive. This same sequence features parodies of ''SPIN'' magazine and ''The National Enquirer''.

The "Dope Show" video, directed by Paul Hunter and co-directed by [[Marilyn Manson|Manson]], was filmed during the week of August 8, 1998, and premiered on August 20, 1998. In scenes reminiscent of ''The Man Who Fell to Earth'', Manson appears — red-haired, with his entire body, including prosthetic rubber breasts, covered in white grease paint — as an androgynous extraterrestrial wandering around the Hollywood Hills. He is captured, studied in a laboratory, and eventually transported by limousine to a stage where he and the other members of the band — the fictional band Omēga and the Mechanical Animals — perform the song in concert before hysterical fans who end up rioting and crossing the security barriers. Actor Billy Zane makes a cameo appearance in the limo sequence, as a recording industry executive. This same sequence features parodies of ''SPIN'' magazine and ''The National Enquirer''.

"The Dope Show"'s performance sequence was filmed in front of The District Court on North Spring Street. The Brutalist architecture of the Courthouse did not permit a reasonable angle or height from which to film; instead, the band was placed on top of the trailer of an 18-wheeler transport truck. Cameras situated on mechanical arms, and at a distance across the street, were used to film the dramatic concert shots. These scenes are interspersed with cuts of underground drag performer Johnnie Baima, the Goddess Bunny, dancing in a yellow, sequined dress, similar to that worn by Twiggy Ramirez in the same video. The costumes for the video, including the dresses and Marilyn Manson's red, diamond-patterned boots (which featured a 6-inch sole and heel) were designed jointly by Manson and Terri King. The Goddess Bunny's custom couture sequin gown (worn for the live MTV awards performance), was designed and hand sewn by Kris Hendrickson, aka littlemskris of San Francisco.

"The Dope Show"'s performance sequence was filmed in front of The District Court on North Spring Street. The Brutalist architecture of the Courthouse did not permit a reasonable angle or height from which to film; instead, the band was placed on top of the trailer of an 18-wheeler transport truck. Cameras situated on mechanical arms, and at a distance across the street, were used to film the dramatic concert shots. These scenes are interspersed with cuts of underground drag performer Johnnie Baima, the Goddess Bunny, dancing in a yellow, sequined dress, similar to that worn by Twiggy Ramirez in the same video. The costumes for the video, including the dresses and Marilyn Manson's red, diamond-patterned boots (which featured a 6-inch sole and heel) were designed jointly by Manson and Terri King. The Goddess Bunny's custom couture sequin gown (worn for the live MTV awards performance), was designed and hand sewn by Kris Hendrickson, aka littlemskris of San Francisco.